Feeling good is more complicated than it looks. Armand DiMele, joined by Linda Vanella, LCSW-R, and co-host Giullian Gioiello, unpacks the spectrum of gladness, from alert calm to manic highs to nervous laughter, drawing on brain chemistry, fruit fly research, and callers sharing their own deflections from pain.
Serotonin may not cause depression after all. Armand DiMele and Linda Vanella, LCSW-R, dig into why the serotonin hypothesis is crumbling and why neurogenesis, the growth of new brain cells, may better explain how mood shifts with age and how exercise, learning, and enriched environments can counter decline.
The brain was supposed to be sealed off from the immune system, but new research suggests otherwise. Armand DiMele surveys evidence that bacterial infections, antibodies, and T cells can trigger OCD, depression, memory loss, and personality shifts, and that treating the infection sometimes cures the psychiatric symptom.
Feeling good is not a vague mental state but a precise chemical one, and Armand DiMele breaks down how everything from exercise to eating to orgasm is really the body engineering its own neurochemistry. The episode also reframes feeling good as often just the absence of pain.
Research by evolutionary psychologists Gordon Gallup and Rebecca Baruch reveals that semen contains over 50 compounds including cortisol, serotonin, oxytocin, and prolactin. Armand DiMele walks through studies showing women who have condomless sex report significantly lower depression and suicide rates, and considers the ethical weight of publicizing the findings.
Anger is not just emotional but biochemical: cortisol drops, testosterone rises, and the left brain activates when we rage. Armand DiMele and Stephanie D’Ambra, LCSW discuss how anger functions as the body’s shortcut out of depression, why blaming others is an addiction, and what the latest neurochemical research reveals about rage, closeness, and self.
Irritability turns out to be closer to fear than anger, and closer to tears than most people realize. Armand DiMele and Stephanie D’Ambra, LCSW, trace how weather, hormones, serotonin, fatigue, and vitamin D deprivation all converge to push the nervous system toward that hair-trigger state, and callers weigh in with their own experiences.
What happens to the human mind when you’re trapped with strangers in Antarctica or a Mars simulation capsule for months? Emily Anthes, Science Journalist and Author, joins Armand DiMele and Stephanie D’Ambra, LCSW, to examine how extreme isolation, cold, and darkness disrupt mood, hormones, and group cohesion in ways that mirror everyday life under pressure.
Memories shift each time we recall them, and music rewires brain chemistry in ways science is only beginning to confirm. Armand DiMele and co-host Stephanie D’Ambra, LCSW, draw on a recent conference on music and neurological function to explore how rhythm and melody can reach Alzheimer’s and Parkinson’s patients, spark dopamine release, and even mirror the pull of addiction.
Moods are not simply feelings but products of neurotransmitters, nutrition, environment, and psychology working together. Armand DiMele argues that blame and repetitive arguing perpetuate bad moods rather than resolve them, and that a flexible, expansive mind, one open even to nonsense and surprise, is the real tool for change.
